Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study

We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of ep...

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Autores principales: Byng, Martyn C, Fisher, Sheila A, Lewis, Cathryn M, Whittaker, John C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866475/
https://www.ncbi.nlm.nih.gov/pubmed/14975072
http://dx.doi.org/10.1186/1471-2156-4-S1-S4
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author Byng, Martyn C
Fisher, Sheila A
Lewis, Cathryn M
Whittaker, John C
author_facet Byng, Martyn C
Fisher, Sheila A
Lewis, Cathryn M
Whittaker, John C
author_sort Byng, Martyn C
collection PubMed
description We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.
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spelling pubmed-18664752007-05-11 Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study Byng, Martyn C Fisher, Sheila A Lewis, Cathryn M Whittaker, John C BMC Genet Proceedings We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP. BioMed Central 2003-12-31 /pmc/articles/PMC1866475/ /pubmed/14975072 http://dx.doi.org/10.1186/1471-2156-4-S1-S4 Text en Copyright © 2003 Byng et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Byng, Martyn C
Fisher, Sheila A
Lewis, Cathryn M
Whittaker, John C
Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title_full Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title_fullStr Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title_full_unstemmed Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title_short Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study
title_sort variance components linkage analysis for adjusted systolic blood pressure in the framingham heart study
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866475/
https://www.ncbi.nlm.nih.gov/pubmed/14975072
http://dx.doi.org/10.1186/1471-2156-4-S1-S4
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