Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study

BACKGROUND: Genetic heterogeneity and complex biologic mechanisms of blood pressure regulation pose significant challenges to the identification of susceptibility loci influencing hypertension. Previous linkage studies have reported regions of interest, but lack consistency across studies. Incorpora...

Descripción completa

Detalles Bibliográficos
Autores principales: Daley, Denise, Edwards, Shannon R, Song, Yeunjoo, Baechle, Dan, Puppala, Sobha, Schick, JH, Olson, Jane M, Goddard, Katrina AB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866481/
https://www.ncbi.nlm.nih.gov/pubmed/14975113
http://dx.doi.org/10.1186/1471-2156-4-S1-S45
_version_ 1782133280021151744
author Daley, Denise
Edwards, Shannon R
Song, Yeunjoo
Baechle, Dan
Puppala, Sobha
Schick, JH
Olson, Jane M
Goddard, Katrina AB
author_facet Daley, Denise
Edwards, Shannon R
Song, Yeunjoo
Baechle, Dan
Puppala, Sobha
Schick, JH
Olson, Jane M
Goddard, Katrina AB
author_sort Daley, Denise
collection PubMed
description BACKGROUND: Genetic heterogeneity and complex biologic mechanisms of blood pressure regulation pose significant challenges to the identification of susceptibility loci influencing hypertension. Previous linkage studies have reported regions of interest, but lack consistency across studies. Incorporation of covariates, in particular the interaction between two independent risk factors (gender and BMI) greatly improved our ability to detect linkage. RESULTS: We report a highly significant signal for linkage to chromosome 2p, a region that has been implicated in previous linkage studies, along with several suggestive linkage regions. CONCLUSION: We demonstrate the importance of including covariates in the linkage analysis when the phenotype is complex.
format Text
id pubmed-1866481
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-18664812007-05-11 Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study Daley, Denise Edwards, Shannon R Song, Yeunjoo Baechle, Dan Puppala, Sobha Schick, JH Olson, Jane M Goddard, Katrina AB BMC Genet Proceedings BACKGROUND: Genetic heterogeneity and complex biologic mechanisms of blood pressure regulation pose significant challenges to the identification of susceptibility loci influencing hypertension. Previous linkage studies have reported regions of interest, but lack consistency across studies. Incorporation of covariates, in particular the interaction between two independent risk factors (gender and BMI) greatly improved our ability to detect linkage. RESULTS: We report a highly significant signal for linkage to chromosome 2p, a region that has been implicated in previous linkage studies, along with several suggestive linkage regions. CONCLUSION: We demonstrate the importance of including covariates in the linkage analysis when the phenotype is complex. BioMed Central 2003-12-31 /pmc/articles/PMC1866481/ /pubmed/14975113 http://dx.doi.org/10.1186/1471-2156-4-S1-S45 Text en Copyright © 2003 Daley et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Daley, Denise
Edwards, Shannon R
Song, Yeunjoo
Baechle, Dan
Puppala, Sobha
Schick, JH
Olson, Jane M
Goddard, Katrina AB
Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title_full Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title_fullStr Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title_full_unstemmed Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title_short Interaction of gender and body mass index (BMI) reveals evidence of linkage for hypertension in the Framingham Heart Study
title_sort interaction of gender and body mass index (bmi) reveals evidence of linkage for hypertension in the framingham heart study
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866481/
https://www.ncbi.nlm.nih.gov/pubmed/14975113
http://dx.doi.org/10.1186/1471-2156-4-S1-S45
work_keys_str_mv AT daleydenise interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT edwardsshannonr interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT songyeunjoo interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT baechledan interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT puppalasobha interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT schickjh interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT olsonjanem interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy
AT goddardkatrinaab interactionofgenderandbodymassindexbmirevealsevidenceoflinkageforhypertensionintheframinghamheartstudy

Ejemplares similares