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Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects
BACKGROUND: We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting glucose, HDL cholesterol, blood pressure, and triglycerides), and one derived quanti...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866498/ https://www.ncbi.nlm.nih.gov/pubmed/14975128 http://dx.doi.org/10.1186/1471-2156-4-S1-S60 |
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author | Ulgen, Ayse Han, Zhihua Li, Wentian |
author_facet | Ulgen, Ayse Han, Zhihua Li, Wentian |
author_sort | Ulgen, Ayse |
collection | PubMed |
description | BACKGROUND: We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting glucose, HDL cholesterol, blood pressure, and triglycerides), and one derived quantitative trait (total cholesterol divided by the HDL cholesterol) are used for phenotype correlation studies. Four of them are used for linkage analysis. RESULTS: We show that although correlation among phenotypes partially reflects the correlation among linkage analysis results, the LOD-score correlations are on average low. The most significant peaks found by using different traits do not often overlap. CONCLUSION: Studying covariances at specific locations in LOD scores may provide clues for further bivariate linkage analyses. |
format | Text |
id | pubmed-1866498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18664982007-05-11 Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects Ulgen, Ayse Han, Zhihua Li, Wentian BMC Genet Proceedings BACKGROUND: We address the question of whether statistical correlations among quantitative traits lead to correlation of linkage results of these traits. Five measured quantitative traits (total cholesterol, fasting glucose, HDL cholesterol, blood pressure, and triglycerides), and one derived quantitative trait (total cholesterol divided by the HDL cholesterol) are used for phenotype correlation studies. Four of them are used for linkage analysis. RESULTS: We show that although correlation among phenotypes partially reflects the correlation among linkage analysis results, the LOD-score correlations are on average low. The most significant peaks found by using different traits do not often overlap. CONCLUSION: Studying covariances at specific locations in LOD scores may provide clues for further bivariate linkage analyses. BioMed Central 2003-12-31 /pmc/articles/PMC1866498/ /pubmed/14975128 http://dx.doi.org/10.1186/1471-2156-4-S1-S60 Text en Copyright © 2003 Ulgen et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Proceedings Ulgen, Ayse Han, Zhihua Li, Wentian Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title | Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title_full | Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title_fullStr | Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title_full_unstemmed | Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title_short | Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects |
title_sort | correlation between quantitative traits and correlation between corresponding lod scores: detection of pleiotropic effects |
topic | Proceedings |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866498/ https://www.ncbi.nlm.nih.gov/pubmed/14975128 http://dx.doi.org/10.1186/1471-2156-4-S1-S60 |
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