Genome-wide linkage analysis of blood pressure under locus heterogeneity

We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Xinqun, Wang, Kai, Huang, Jian, Vieland, Veronica J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866517/
https://www.ncbi.nlm.nih.gov/pubmed/14975146
http://dx.doi.org/10.1186/1471-2156-4-S1-S78
_version_ 1782133290425122816
author Yang, Xinqun
Wang, Kai
Huang, Jian
Vieland, Veronica J
author_facet Yang, Xinqun
Wang, Kai
Huang, Jian
Vieland, Veronica J
author_sort Yang, Xinqun
collection PubMed
description We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals.
format Text
id pubmed-1866517
institution National Center for Biotechnology Information
language English
publishDate 2003
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-18665172007-05-11 Genome-wide linkage analysis of blood pressure under locus heterogeneity Yang, Xinqun Wang, Kai Huang, Jian Vieland, Veronica J BMC Genet Proceedings We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and 049xd2) at a significance level of 0.01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals. BioMed Central 2003-12-31 /pmc/articles/PMC1866517/ /pubmed/14975146 http://dx.doi.org/10.1186/1471-2156-4-S1-S78 Text en Copyright © 2003 Yang et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Yang, Xinqun
Wang, Kai
Huang, Jian
Vieland, Veronica J
Genome-wide linkage analysis of blood pressure under locus heterogeneity
title Genome-wide linkage analysis of blood pressure under locus heterogeneity
title_full Genome-wide linkage analysis of blood pressure under locus heterogeneity
title_fullStr Genome-wide linkage analysis of blood pressure under locus heterogeneity
title_full_unstemmed Genome-wide linkage analysis of blood pressure under locus heterogeneity
title_short Genome-wide linkage analysis of blood pressure under locus heterogeneity
title_sort genome-wide linkage analysis of blood pressure under locus heterogeneity
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866517/
https://www.ncbi.nlm.nih.gov/pubmed/14975146
http://dx.doi.org/10.1186/1471-2156-4-S1-S78
work_keys_str_mv AT yangxinqun genomewidelinkageanalysisofbloodpressureunderlocusheterogeneity
AT wangkai genomewidelinkageanalysisofbloodpressureunderlocusheterogeneity
AT huangjian genomewidelinkageanalysisofbloodpressureunderlocusheterogeneity
AT vielandveronicaj genomewidelinkageanalysisofbloodpressureunderlocusheterogeneity

Ejemplares similares