Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis

BACKGROUND: Often, multiple measures of a trait are available in a genetic linkage analysis. We compare Monte Carlo Markov chain analysis of two very different measures of hypertension in the simulated Genetic Analysis Workshop 13 data to examine how choice of measure affects the results. The measur...

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Autores principales: Daw, E Warwick, Liu, Xiaoming, Wu, Chih-Chieh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866520/
https://www.ncbi.nlm.nih.gov/pubmed/14975148
http://dx.doi.org/10.1186/1471-2156-4-S1-S80
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author Daw, E Warwick
Liu, Xiaoming
Wu, Chih-Chieh
author_facet Daw, E Warwick
Liu, Xiaoming
Wu, Chih-Chieh
author_sort Daw, E Warwick
collection PubMed
description BACKGROUND: Often, multiple measures of a trait are available in a genetic linkage analysis. We compare Monte Carlo Markov chain analysis of two very different measures of hypertension in the simulated Genetic Analysis Workshop 13 data to examine how choice of measure affects the results. The measures selected were age-of-onset of hypertension and systolic blood pressure at first visit. RESULTS: In combined segregation and linkage analysis of the complete pedigrees using the first replicate of the simulated data with missing values, we found that the age-of-onset analysis was better at identifying "slope" genes, while the systolic blood pressure analysis was better at identifying "baseline" genes. CONCLUSION: Analysis of different trait measures may identify different trait-related genes. When linkage analysis is conducted on multiple trait measures, a linkage signal found for only one measure can represent a true trait locus.
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spelling pubmed-18665202007-05-11 Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis Daw, E Warwick Liu, Xiaoming Wu, Chih-Chieh BMC Genet Proceedings BACKGROUND: Often, multiple measures of a trait are available in a genetic linkage analysis. We compare Monte Carlo Markov chain analysis of two very different measures of hypertension in the simulated Genetic Analysis Workshop 13 data to examine how choice of measure affects the results. The measures selected were age-of-onset of hypertension and systolic blood pressure at first visit. RESULTS: In combined segregation and linkage analysis of the complete pedigrees using the first replicate of the simulated data with missing values, we found that the age-of-onset analysis was better at identifying "slope" genes, while the systolic blood pressure analysis was better at identifying "baseline" genes. CONCLUSION: Analysis of different trait measures may identify different trait-related genes. When linkage analysis is conducted on multiple trait measures, a linkage signal found for only one measure can represent a true trait locus. BioMed Central 2003-12-31 /pmc/articles/PMC1866520/ /pubmed/14975148 http://dx.doi.org/10.1186/1471-2156-4-S1-S80 Text en Copyright © 2003 Daw et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Daw, E Warwick
Liu, Xiaoming
Wu, Chih-Chieh
Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title_full Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title_fullStr Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title_full_unstemmed Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title_short Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
title_sort age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866520/
https://www.ncbi.nlm.nih.gov/pubmed/14975148
http://dx.doi.org/10.1186/1471-2156-4-S1-S80
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AT liuxiaoming ageofonsetofhypertensionvsasinglemeasurementofsystolicbloodpressureinacombinedlinkageandsegregationanalysis
AT wuchihchieh ageofonsetofhypertensionvsasinglemeasurementofsystolicbloodpressureinacombinedlinkageandsegregationanalysis

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