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Robust testing of haplotype/disease association

Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data are available, statistical approaches need to be employed to resolve haplotype phase ambigui...

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Detalles Bibliográficos
Autores principales: Allen, Andrew S, Satten, Glen A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866713/
https://www.ncbi.nlm.nih.gov/pubmed/16451682
http://dx.doi.org/10.1186/1471-2156-6-S1-S69
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author Allen, Andrew S
Satten, Glen A
author_facet Allen, Andrew S
Satten, Glen A
author_sort Allen, Andrew S
collection PubMed
description Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data are available, statistical approaches need to be employed to resolve haplotype phase ambiguity. Recently, we have proposed an approach to testing and estimating haplotype/disease association that is invariant to any existing genetic structure in the population. Here we evaluate this approach by applying it to the Genetic Analysis Workshop 14 simulated data.
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spelling pubmed-18667132007-05-11 Robust testing of haplotype/disease association Allen, Andrew S Satten, Glen A BMC Genet Proceedings Haplotypes, the combination of closely linked alleles that fall on the same chromosome, show great promise for studying the genetic components of complex diseases. However, when only multilocus genotype data are available, statistical approaches need to be employed to resolve haplotype phase ambiguity. Recently, we have proposed an approach to testing and estimating haplotype/disease association that is invariant to any existing genetic structure in the population. Here we evaluate this approach by applying it to the Genetic Analysis Workshop 14 simulated data. BioMed Central 2005-12-30 /pmc/articles/PMC1866713/ /pubmed/16451682 http://dx.doi.org/10.1186/1471-2156-6-S1-S69 Text en Copyright © 2005 Allen and Satten; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Allen, Andrew S
Satten, Glen A
Robust testing of haplotype/disease association
title Robust testing of haplotype/disease association
title_full Robust testing of haplotype/disease association
title_fullStr Robust testing of haplotype/disease association
title_full_unstemmed Robust testing of haplotype/disease association
title_short Robust testing of haplotype/disease association
title_sort robust testing of haplotype/disease association
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866713/
https://www.ncbi.nlm.nih.gov/pubmed/16451682
http://dx.doi.org/10.1186/1471-2156-6-S1-S69
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