Cargando…

Smoothing of the bivariate LOD score for non-normal quantitative traits

Variance component analysis provides an efficient method for performing linkage analysis for quantitative traits. However, type I error of variance components-based likelihood ratio testing may be affected when phenotypic data are non-normally distributed (especially with high values of kurtosis). T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buil, Alfonso, Dyer, Thomas D, Almasy, Laura, Blangero, John
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866827/ https://www.ncbi.nlm.nih.gov/pubmed/16451568 http://dx.doi.org/10.1186/1471-2156-6-S1-S111

Ejemplares similares

A power study of bivariate LOD score analysis of a complex trait and fear/discomfort with strangers
por: Ji, Fei, et al.
Publicado: (2005)

Comparison of multipoint linkage analyses for quantitative traits in the CEPH data: parametric LOD scores, variance components LOD scores, and Bayes factors
por: Sung, Yun Ju, et al.
Publicado: (2007)

Correlation between quantitative traits and correlation between corresponding LOD scores: detection of pleiotropic effects
por: Ulgen, Ayse, et al.
Publicado: (2003)

A comparison of univariate, bivariate, and trivariate whole-genome linkage screens of genetically correlated electrophysiological endophenotypes
por: Warren, Diane M, et al.
Publicado: (2005)

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait
por: Knight, Jo, et al.
Publicado: (2003)

Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
por: Arya, Rector, et al.
Publicado: (2003)

Bivariate association analysis of longitudinal phenotypes in families
por: Melton, Phillip E, et al.
Publicado: (2014)

Joint association analysis of bivariate quantitative and qualitative traits
por: Yuan, Mengdie, et al.
Publicado: (2011)

A comparison of discrete versus continuous environment in a variance components-based linkage analysis of the COGA data
por: Viel, Kevin R, et al.
Publicado: (2005)

The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification
por: Havill, Lorena M, et al.
Publicado: (2005)

Linkage disequilibrium across two different single-nucleotide polymorphism genome scans
por: Peralta, Juan Manuel, et al.
Publicado: (2005)

Strategy and model building in the fourth dimension: a null model for genotype × age interaction as a Gaussian stationary stochastic process
por: Diego, Vincent P, et al.
Publicado: (2003)

Genetic signal maximization using environmental regression
por: Melton, Phillip E, et al.
Publicado: (2011)

Genome-wide discovery of maternal effect variants
por: Kent, Jack W, et al.
Publicado: (2009)

Effects on linkage analyses of different Affymetrix expression measures as quantitative trait phenotypes
por: Peralta, Juan Manuel, et al.
Publicado: (2007)

X chromosome effects and their interactions with mitochondrial effects
por: Kent, Jack W, et al.
Publicado: (2005)

Do rare variant genotypes predict common variant genotypes?
por: Kent, Jack W, et al.
Publicado: (2011)

Toward the identification of causal genes in complex diseases: a gene-centric joint test of significance combining genomic and transcriptomic data
por: Charlesworth, Jac C, et al.
Publicado: (2009)

Effect of genotype × alcoholism interaction on linkage analysis of an alcoholism-related quantitative phenotype
por: Arya, Rector, et al.
Publicado: (2005)

A variance component method for integrated pathway analysis of gene expression data
por: Quillen, Ellen E., et al.
Publicado: (2016)

Genetic Analysis Workshop 17 mini-exome simulation
por: Almasy, Laura, et al.
Publicado: (2011)

Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
por: Franceschini, Nora, et al.
Publicado: (2007)

On normality, ethnicity, and missing values in quantitative trait locus mapping
por: Labbe, Aurélie, et al.
Publicado: (2005)

Normalizing a large number of quantitative traits using empirical normal quantile transformation
por: Peng, Bo, et al.
Publicado: (2007)

Searching for master regulators of transcription in a human gene expression data set
por: Buil, Alfonso, et al.
Publicado: (2007)

Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study
por: Zhang, Xuyang, et al.
Publicado: (2003)

Estimating genomic breeding values and detecting QTL using univariate and bivariate models
por: Calus, Mario PL, et al.
Publicado: (2011)

Bivariate genetic association analysis of systolic and diastolic blood pressure by copula models
por: Konigorski, Stefan, et al.
Publicado: (2014)

Sex-Specific Regulation of Mitochondrial DNA Levels: Genome-Wide Linkage Analysis to Identify Quantitative Trait Loci
por: López, Sonia, et al.
Publicado: (2012)

Application of bivariate mixed counting process models to genetic analysis of rheumatoid arthritis severity
por: Sutradhar, Rinku, et al.
Publicado: (2007)

Family-Based Bivariate Association Tests for Quantitative Traits
por: Zhang, Lei, et al.
Publicado: (2009)

On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
por: Göring, Harald HH, et al.
Publicado: (2003)

Mitochondrial genetic effects on latent class variables associated with susceptibility to alcoholism
por: Lease, Loren R, et al.
Publicado: (2005)

Evaluation of estimated genetic values and their application to genome-wide investigation of systolic blood pressure
por: Quillen, Ellen E, et al.
Publicado: (2014)

Bivariate variance-component analysis, with application to systolic blood pressure and total cholesterol levels in the Framingham Heart Study
por: Cui, Jisheng S, et al.
Publicado: (2003)

Bivariate linear mixed model analysis to test joint associations of genetic variants on systolic and diastolic blood pressure
por: Neupane, Binod, et al.
Publicado: (2014)

Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic
por: Hendricks, Audrey E, et al.
Publicado: (2009)

Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees
por: Almasy, Laura, et al.
Publicado: (2014)

A new method for identifying bivariate differential expression in high dimensional microarray data using quadratic discriminant analysis
por: Arevalillo, Jorge M, et al.
Publicado: (2011)

Evaluating epistatic interaction signals in complex traits using quantitative traits
por: Mukherjee, Odity, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_tf151gg4qnubgj1fm5nq42i8r9