How to quantify information loss due to phase ambiguity in haplotype case-control studies

Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambig...

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Detalles Bibliográficos
Autores principales: Uh, Hae-Won, Houwing-Duistermaat, Jeanine J, Putter, Hein, van Houwelingen, Hans C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866831/
https://www.ncbi.nlm.nih.gov/pubmed/16451564
http://dx.doi.org/10.1186/1471-2156-6-S1-S108
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author Uh, Hae-Won
Houwing-Duistermaat, Jeanine J
Putter, Hein
van Houwelingen, Hans C
author_facet Uh, Hae-Won
Houwing-Duistermaat, Jeanine J
Putter, Hein
van Houwelingen, Hans C
author_sort Uh, Hae-Won
collection PubMed
description Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information.
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spelling pubmed-18668312007-05-11 How to quantify information loss due to phase ambiguity in haplotype case-control studies Uh, Hae-Won Houwing-Duistermaat, Jeanine J Putter, Hein van Houwelingen, Hans C BMC Genet Proceedings Assigning haplotypes in a case-control study is a challenging problem. We proposed a method to quantify the information loss due to missing phase information. We determined which individuals were responsible for the information loss, and calculated how much information could be gained when the ambiguous individuals could be resolved by adding additional parental information. BioMed Central 2005-12-30 /pmc/articles/PMC1866831/ /pubmed/16451564 http://dx.doi.org/10.1186/1471-2156-6-S1-S108 Text en Copyright © 2005 Uh et al; licensee BioMed Central Ltd http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Uh, Hae-Won
Houwing-Duistermaat, Jeanine J
Putter, Hein
van Houwelingen, Hans C
How to quantify information loss due to phase ambiguity in haplotype case-control studies
title How to quantify information loss due to phase ambiguity in haplotype case-control studies
title_full How to quantify information loss due to phase ambiguity in haplotype case-control studies
title_fullStr How to quantify information loss due to phase ambiguity in haplotype case-control studies
title_full_unstemmed How to quantify information loss due to phase ambiguity in haplotype case-control studies
title_short How to quantify information loss due to phase ambiguity in haplotype case-control studies
title_sort how to quantify information loss due to phase ambiguity in haplotype case-control studies
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866831/
https://www.ncbi.nlm.nih.gov/pubmed/16451564
http://dx.doi.org/10.1186/1471-2156-6-S1-S108
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