Structural Insights into the Evolution of a Non-Biological Protein: Importance of Surface Residues in Protein Fold Optimization

Phylogenetic profiling of amino acid substitution patterns in proteins has led many to conclude that most structural information is carried by interior core residues that are solvent inaccessible. This conclusion is based on the observation that buried residues generally tolerate only conserved sequ...

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Detalles Bibliográficos
Autores principales: Smith, Matthew D., Rosenow, Matthew A., Wang, Meitian, Allen, James P., Szostak, Jack W., Chaput, John C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867856/
https://www.ncbi.nlm.nih.gov/pubmed/17520026
http://dx.doi.org/10.1371/journal.pone.0000467

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