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PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-β/EGFR signaling promotes cell migration and induces expression of both...

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Detalles Bibliográficos
Autores principales:	Wilkins-Port, Cynthia E., Higgins, Craig E., Freytag, Jennifer, Higgins, Stephen P., Carlson, J. Andrew, Higgins, Paul J.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2007
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868077/ https://www.ncbi.nlm.nih.gov/pubmed/17515947 http://dx.doi.org/10.1155/2007/85208

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