Cargando…
Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report
This report regards the case of a 43 year-old HIV-positive woman who developed an episode of serious transaminase elevation during stavudine-including antiretroviral therapy. Diagnostic assessment ruled out hepatitis virus co-infection, alcohol abuse besides other possible causes of liver damage. No...
Autores principales: | , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868747/ https://www.ncbi.nlm.nih.gov/pubmed/17488516 http://dx.doi.org/10.1186/1752-1947-1-19 |
_version_ | 1782133397651456000 |
---|---|
author | Lapadula, Giuseppe Izzo, Ilaria Costarelli, Silvia Cologni, Giuliana Bercich, Luisa Casari, Salvatore Gambarotti, Marco Torti, Carlo |
author_facet | Lapadula, Giuseppe Izzo, Ilaria Costarelli, Silvia Cologni, Giuliana Bercich, Luisa Casari, Salvatore Gambarotti, Marco Torti, Carlo |
author_sort | Lapadula, Giuseppe |
collection | PubMed |
description | This report regards the case of a 43 year-old HIV-positive woman who developed an episode of serious transaminase elevation during stavudine-including antiretroviral therapy. Diagnostic assessment ruled out hepatitis virus co-infection, alcohol abuse besides other possible causes of liver damage. No signs of lactic acidosis were present. Liver biopsy showed portal inflammatory infiltrate, spotty necrosis, vacuoles of macro- and micro-vesicular steatosis, acidophil and foamy hepatocytes degeneration with organelles clumping, poorly formed Mallory bodies and neutrophil granulocytes attraction (satellitosis). A dramatic improvement in liver function tests occurred when stavudine was discontinued and a new antiretroviral regimen with different nucleoside reverse transcriptase inhibitors was used. The importance of considering hepatotoxicity as an adverse event of HAART including stavudine, even in absence of other signs of mitochondrial toxicity should therefore be underlined. Liver biopsy may provide further important information regarding patients with severe transaminase elevation, for a better understanding of the etiology of liver damage. |
format | Text |
id | pubmed-1868747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18687472007-05-15 Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report Lapadula, Giuseppe Izzo, Ilaria Costarelli, Silvia Cologni, Giuliana Bercich, Luisa Casari, Salvatore Gambarotti, Marco Torti, Carlo J Med Case Reports Case Report This report regards the case of a 43 year-old HIV-positive woman who developed an episode of serious transaminase elevation during stavudine-including antiretroviral therapy. Diagnostic assessment ruled out hepatitis virus co-infection, alcohol abuse besides other possible causes of liver damage. No signs of lactic acidosis were present. Liver biopsy showed portal inflammatory infiltrate, spotty necrosis, vacuoles of macro- and micro-vesicular steatosis, acidophil and foamy hepatocytes degeneration with organelles clumping, poorly formed Mallory bodies and neutrophil granulocytes attraction (satellitosis). A dramatic improvement in liver function tests occurred when stavudine was discontinued and a new antiretroviral regimen with different nucleoside reverse transcriptase inhibitors was used. The importance of considering hepatotoxicity as an adverse event of HAART including stavudine, even in absence of other signs of mitochondrial toxicity should therefore be underlined. Liver biopsy may provide further important information regarding patients with severe transaminase elevation, for a better understanding of the etiology of liver damage. BioMed Central 2007-05-08 /pmc/articles/PMC1868747/ /pubmed/17488516 http://dx.doi.org/10.1186/1752-1947-1-19 Text en Copyright © 2007 Lapadula et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Lapadula, Giuseppe Izzo, Ilaria Costarelli, Silvia Cologni, Giuliana Bercich, Luisa Casari, Salvatore Gambarotti, Marco Torti, Carlo Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title | Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title_full | Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title_fullStr | Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title_full_unstemmed | Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title_short | Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
title_sort | dideoxynucleoside hiv reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868747/ https://www.ncbi.nlm.nih.gov/pubmed/17488516 http://dx.doi.org/10.1186/1752-1947-1-19 |
work_keys_str_mv | AT lapadulagiuseppe dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT izzoilaria dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT costarellisilvia dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT colognigiuliana dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT bercichluisa dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT casarisalvatore dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT gambarottimarco dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport AT torticarlo dideoxynucleosidehivreversetranscriptaseinhibitorsanddrugrelatedhepatotoxicityacasereport |