Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

The nucleolus is the site of ribosome synthesis in the nucleus, whose integrity is essential. Epigenetic mechanisms are thought to regulate the activity of the ribosomal RNA (rRNA) gene copies, which are part of the nucleolus. Here we show that human cells lacking DNA methyltransferase 1 (Dnmt1), bu...

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Detalles Bibliográficos
Autores principales: Espada, Jesús, Ballestar, Esteban, Santoro, Raffaella, Fraga, Mario F., Villar-Garea, Ana, Németh, Attila, Lopez-Serra, Lidia, Ropero, Santiago, Aranda, Agustin, Orozco, Helena, Moreno, Vanessa, Juarranz, Angeles, Stockert, Juan Carlos, Längst, Gernot, Grummt, Ingrid, Bickmore, Wendy, Esteller, Manel
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874631/
https://www.ncbi.nlm.nih.gov/pubmed/17355984
http://dx.doi.org/10.1093/nar/gkm118

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