Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR

Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with n...

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Detalles Bibliográficos
Autores principales: Vadlamudi, Ratna K., Kumar, Rakesh
Formato: Texto
Lenguaje:English
Publicado: The Nuclear Receptor Signaling Atlas 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876599/
https://www.ncbi.nlm.nih.gov/pubmed/17525794
http://dx.doi.org/10.1621/nrs.05004
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author Vadlamudi, Ratna K.
Kumar, Rakesh
author_facet Vadlamudi, Ratna K.
Kumar, Rakesh
author_sort Vadlamudi, Ratna K.
collection PubMed
description Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.
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spelling pubmed-18765992007-05-24 Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR Vadlamudi, Ratna K. Kumar, Rakesh Nucl Recept Signal Review Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR. The Nuclear Receptor Signaling Atlas 2007-05-17 /pmc/articles/PMC1876599/ /pubmed/17525794 http://dx.doi.org/10.1621/nrs.05004 Text en Copyright © 2007, Vadlamudi and Kumar. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Vadlamudi, Ratna K.
Kumar, Rakesh
Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title_full Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title_fullStr Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title_full_unstemmed Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title_short Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR
title_sort functional and biological properties of the nuclear receptor coregulator pelp1/mnar
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876599/
https://www.ncbi.nlm.nih.gov/pubmed/17525794
http://dx.doi.org/10.1621/nrs.05004
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