An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH(4)O...

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Autores principales: Ghozlan, Said A S, Badahdah, Khadija O, Abdelhamid, Ismail A
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2007
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885264/
https://www.ncbi.nlm.nih.gov/pubmed/17470302
http://dx.doi.org/10.1186/1860-5397-3-15
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author Ghozlan, Said A S
Badahdah, Khadija O
Abdelhamid, Ismail A
author_facet Ghozlan, Said A S
Badahdah, Khadija O
Abdelhamid, Ismail A
author_sort Ghozlan, Said A S
collection PubMed
description 3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH(4)OAc respectively.
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spelling pubmed-18852642007-05-31 An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues Ghozlan, Said A S Badahdah, Khadija O Abdelhamid, Ismail A Beilstein J Org Chem Full Research Paper 3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH(4)OAc respectively. Beilstein-Institut 2007-05-01 /pmc/articles/PMC1885264/ /pubmed/17470302 http://dx.doi.org/10.1186/1860-5397-3-15 Text en Copyright © 2007, Ghozlan et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Ghozlan, Said A S
Badahdah, Khadija O
Abdelhamid, Ismail A
An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title_full An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title_fullStr An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title_full_unstemmed An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title_short An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
title_sort easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885264/
https://www.ncbi.nlm.nih.gov/pubmed/17470302
http://dx.doi.org/10.1186/1860-5397-3-15
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