Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

A critical issue in understanding Huntington's disease (HD) pathogenesis is how the ubiquitously expressed mutant huntingtin (mhtt) with an expanded polyglutamine repeat can cause selective toxicity of striatal and cortical neurons. Two potential cellular models may contribute to such specifici...

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Detalles Bibliográficos
Autores principales: Gu, Xiaofeng, André, Véronique M, Cepeda, Carlos, Li, Shi-Hua, Li, Xiao-Jiang, Levine, Michael S, Yang, X William
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885431/
https://www.ncbi.nlm.nih.gov/pubmed/17470275
http://dx.doi.org/10.1186/1750-1326-2-8

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