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Identification and characterization of OGG1 mutations in patients with Alzheimer's disease

Patients with Alzheimer's disease (AD) exhibit higher levels of 8-oxo-guanine (8-oxoG) DNA lesions in their brain, suggesting a reduced or defective 8-oxoG repair. To test this hypothesis, this study investigated 14 AD patients and 10 age-matched controls for mutations of the major 8-oxoG remov...

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Detalles Bibliográficos
Autores principales:	Mao, Guogen, Pan, Xiaoyu, Zhu, Bei-Bei, Zhang, Yanbin, Yuan, Fenghua, Huang, Jian, Lovell, Mark A., Lee, Maxwell P., Markesbery, William R., Li, Guo-Min, Gu, Liya
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885677/ https://www.ncbi.nlm.nih.gov/pubmed/17426120 http://dx.doi.org/10.1093/nar/gkm189

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