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Principles of Genome Evolution in the Drosophila melanogaster Species Group

That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ectopic recombination events between inverted repet...

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Autores principales: Ranz, José M, Maurin, Damien, Chan, Yuk S, von Grotthuss, Marcin, Hillier, LaDeana W, Roote, John, Ashburner, Michael, Bergman, Casey M
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885836/
https://www.ncbi.nlm.nih.gov/pubmed/17550304
http://dx.doi.org/10.1371/journal.pbio.0050152
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author Ranz, José M
Maurin, Damien
Chan, Yuk S
von Grotthuss, Marcin
Hillier, LaDeana W
Roote, John
Ashburner, Michael
Bergman, Casey M
author_facet Ranz, José M
Maurin, Damien
Chan, Yuk S
von Grotthuss, Marcin
Hillier, LaDeana W
Roote, John
Ashburner, Michael
Bergman, Casey M
author_sort Ranz, José M
collection PubMed
description That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ectopic recombination events between inverted repetitive sequences. The availability of genome sequences of related species now allows us to study in detail the mechanisms that generate interspecific inversions. We have analyzed the breakpoint regions of the 29 inversions that differentiate the chromosomes of Drosophila melanogaster and two closely related species, D. simulans and D. yakuba, and reconstructed the molecular events that underlie their origin. Experimental and computational analysis revealed that the breakpoint regions of 59% of the inversions (17/29) are associated with inverted duplications of genes or other nonrepetitive sequences. In only two cases do we find evidence for inverted repetitive sequences in inversion breakpoints. We propose that the presence of inverted duplications associated with inversion breakpoint regions is the result of staggered breaks, either isochromatid or chromatid, and that this, rather than ectopic exchange between inverted repetitive sequences, is the prevalent mechanism for the generation of inversions in the melanogaster species group. Outgroup analysis also revealed evidence for widespread breakpoint recycling. Lastly, we have found that expression domains in D. melanogaster may be disrupted in D. yakuba, bringing into question their potential adaptive significance.
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spelling pubmed-18858362007-06-05 Principles of Genome Evolution in the Drosophila melanogaster Species Group Ranz, José M Maurin, Damien Chan, Yuk S von Grotthuss, Marcin Hillier, LaDeana W Roote, John Ashburner, Michael Bergman, Casey M PLoS Biol Research Article That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ectopic recombination events between inverted repetitive sequences. The availability of genome sequences of related species now allows us to study in detail the mechanisms that generate interspecific inversions. We have analyzed the breakpoint regions of the 29 inversions that differentiate the chromosomes of Drosophila melanogaster and two closely related species, D. simulans and D. yakuba, and reconstructed the molecular events that underlie their origin. Experimental and computational analysis revealed that the breakpoint regions of 59% of the inversions (17/29) are associated with inverted duplications of genes or other nonrepetitive sequences. In only two cases do we find evidence for inverted repetitive sequences in inversion breakpoints. We propose that the presence of inverted duplications associated with inversion breakpoint regions is the result of staggered breaks, either isochromatid or chromatid, and that this, rather than ectopic exchange between inverted repetitive sequences, is the prevalent mechanism for the generation of inversions in the melanogaster species group. Outgroup analysis also revealed evidence for widespread breakpoint recycling. Lastly, we have found that expression domains in D. melanogaster may be disrupted in D. yakuba, bringing into question their potential adaptive significance. Public Library of Science 2007-06 2007-06-05 /pmc/articles/PMC1885836/ /pubmed/17550304 http://dx.doi.org/10.1371/journal.pbio.0050152 Text en © 2007 Ranz et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Ranz, José M
Maurin, Damien
Chan, Yuk S
von Grotthuss, Marcin
Hillier, LaDeana W
Roote, John
Ashburner, Michael
Bergman, Casey M
Principles of Genome Evolution in the Drosophila melanogaster Species Group
title Principles of Genome Evolution in the Drosophila melanogaster Species Group
title_full Principles of Genome Evolution in the Drosophila melanogaster Species Group
title_fullStr Principles of Genome Evolution in the Drosophila melanogaster Species Group
title_full_unstemmed Principles of Genome Evolution in the Drosophila melanogaster Species Group
title_short Principles of Genome Evolution in the Drosophila melanogaster Species Group
title_sort principles of genome evolution in the drosophila melanogaster species group
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885836/
https://www.ncbi.nlm.nih.gov/pubmed/17550304
http://dx.doi.org/10.1371/journal.pbio.0050152
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