p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation...

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Autores principales: Hooper, Claudie, Meimaridou, Eirini, Tavassoli, Mahvash, Melino, Gerry, Lovestone, Simon, Killick, Richard
Formato: Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885960/
https://www.ncbi.nlm.nih.gov/pubmed/17399897
http://dx.doi.org/10.1016/j.neulet.2007.03.026
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author Hooper, Claudie
Meimaridou, Eirini
Tavassoli, Mahvash
Melino, Gerry
Lovestone, Simon
Killick, Richard
author_facet Hooper, Claudie
Meimaridou, Eirini
Tavassoli, Mahvash
Melino, Gerry
Lovestone, Simon
Killick, Richard
author_sort Hooper, Claudie
collection PubMed
description p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies.
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spelling pubmed-18859602007-06-11 p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells Hooper, Claudie Meimaridou, Eirini Tavassoli, Mahvash Melino, Gerry Lovestone, Simon Killick, Richard Neurosci Lett Article p53 and tau are both associated with neurodegenerative disorders. Here, we show by Western blotting that p53 is upregulated approximately 2-fold in the superior temporal gyrus of Alzheimer's patients compared to healthy elderly control subjects. Moreover, p53 was found to induce phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells. Confocal microscopy revealed that tau and p53 were spatially separated intracellularly. Tau was found in the cytoskeletal compartment, whilst p53 was located in the nucleus, indicating that the effects of p53 on tau phosphorylation are indirect. Collectively, these findings have ramifications for neuronal death associated with Alzheimer's disease and other tauopathies. Elsevier Scientific Publishers Ireland 2007-05-11 /pmc/articles/PMC1885960/ /pubmed/17399897 http://dx.doi.org/10.1016/j.neulet.2007.03.026 Text en © 2007 Elsevier Ireland Ltd. This document may be redistributed and reused, subject to certain conditions (http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0) .
spellingShingle Article
Hooper, Claudie
Meimaridou, Eirini
Tavassoli, Mahvash
Melino, Gerry
Lovestone, Simon
Killick, Richard
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title_full p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title_fullStr p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title_full_unstemmed p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title_short p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
title_sort p53 is upregulated in alzheimer's disease and induces tau phosphorylation in hek293a cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885960/
https://www.ncbi.nlm.nih.gov/pubmed/17399897
http://dx.doi.org/10.1016/j.neulet.2007.03.026
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