The Dynamics of Signal Triggering in a gp130-Receptor Complex

gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containi...

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Detalles Bibliográficos
Autores principales: Matadeen, Rishi, Hon, Wai-Ching, Heath, John K., Jones, E. Yvonne, Fuller, Stephen
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885967/
https://www.ncbi.nlm.nih.gov/pubmed/17437716
http://dx.doi.org/10.1016/j.str.2007.02.006
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author Matadeen, Rishi
Hon, Wai-Ching
Heath, John K.
Jones, E. Yvonne
Fuller, Stephen
author_facet Matadeen, Rishi
Hon, Wai-Ching
Heath, John K.
Jones, E. Yvonne
Fuller, Stephen
author_sort Matadeen, Rishi
collection PubMed
description gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade.
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spelling pubmed-18859672007-06-11 The Dynamics of Signal Triggering in a gp130-Receptor Complex Matadeen, Rishi Hon, Wai-Ching Heath, John K. Jones, E. Yvonne Fuller, Stephen Structure Article gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin 11(IL-11)-IL-11 Receptor-gp130 extracellular complex reveals the architecture and dynamics of this gp130-containing signaling complex. Normal-mode analysis reveals a repertoire of conformational changes that could function in signal triggering. This suggests a concerted mechanism of signaling involving all the components of the complex. This could provide a general mechanism of signal transfer for cytokines utilizing the JAK-STAT signaling cascade. Cell Press 2007-04 /pmc/articles/PMC1885967/ /pubmed/17437716 http://dx.doi.org/10.1016/j.str.2007.02.006 Text en © 2007 ELL & Excerpta Medica. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Matadeen, Rishi
Hon, Wai-Ching
Heath, John K.
Jones, E. Yvonne
Fuller, Stephen
The Dynamics of Signal Triggering in a gp130-Receptor Complex
title The Dynamics of Signal Triggering in a gp130-Receptor Complex
title_full The Dynamics of Signal Triggering in a gp130-Receptor Complex
title_fullStr The Dynamics of Signal Triggering in a gp130-Receptor Complex
title_full_unstemmed The Dynamics of Signal Triggering in a gp130-Receptor Complex
title_short The Dynamics of Signal Triggering in a gp130-Receptor Complex
title_sort dynamics of signal triggering in a gp130-receptor complex
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885967/
https://www.ncbi.nlm.nih.gov/pubmed/17437716
http://dx.doi.org/10.1016/j.str.2007.02.006
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