Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation

Involvement of the Wiskott-Aldrich syndrome protein (WASp) in promoting cell activation requires its release from autoinhibitory structural constraints and has been attributed to WASp association with activated cdc42. Here, however, we show that T cell development and T cell receptor (TCR)-induced p...

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Detalles Bibliográficos
Autores principales: Badour, Karen, Zhang, Jinyi, Shi, Fabio, Leng, Yan, Collins, Michael, Siminovitch, Katherine A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1887720/
https://www.ncbi.nlm.nih.gov/pubmed/14707117
http://dx.doi.org/10.1084/jem.20030976

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