Sequence analysis of p53 response-elements suggests multiple binding modes of the p53 tetramer to DNA targets

The p53 tetramer recognizes specifically a 20-bp DNA element. Here, we examined symmetries encoded in p53 response elements (p53REs). We analyzed base inversion correlations within the half-site, as well as in the full-site palindrome. We found that p53REs are not only direct repeats of half-sites;...

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Detalles Bibliográficos
Autores principales: Ma, Buyong, Pan, Yongping, Zheng, Jie, Levine, Arnold J., Nussinov, Ruth
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888811/
https://www.ncbi.nlm.nih.gov/pubmed/17439973
http://dx.doi.org/10.1093/nar/gkm192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888811/
https://www.ncbi.nlm.nih.gov/pubmed/17439973
http://dx.doi.org/10.1093/nar/gkm192

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