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An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
Telomere length homeostasis is a prerequisite for the generation and growth of cancer. In >85% cancer cells, telomere length is maintained by telomerase that add telomere repeats to the end of telomere DNA. Because the G-rich strand of telomere DNA can fold into G-quadruplex that inhibits telomer...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888815/ https://www.ncbi.nlm.nih.gov/pubmed/17426118 http://dx.doi.org/10.1093/nar/gkm194 |