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Specificity, duplex degradation and subcellular localization of antagomirs

MicroRNAs (miRNAs) are an abundant class of 20–23-nt long regulators of gene expression. The study of miRNA function in mice and potential therapeutic approaches largely depend on modified oligonucleotides. We recently demonstrated silencing miRNA function in mice using chemically modified and chole...

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Detalles Bibliográficos
Autores principales:	Krützfeldt, Jan, Kuwajima, Satoru, Braich, Ravi, Rajeev, Kallanthottathil G., Pena, John, Tuschl, Thomas, Manoharan, Muthiah, Stoffel, Markus
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888827/ https://www.ncbi.nlm.nih.gov/pubmed/17439965 http://dx.doi.org/10.1093/nar/gkm024

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