Anti-calmodulins and Tricyclic Adjuvants in Pain Therapy Block the TRPV1 Channel

Ca(2+)-loaded calmodulin normally inhibits multiple Ca(2+)-channels upon dangerous elevation of intracellular Ca(2+) and protects cells from Ca(2+)-cytotoxicity, so blocking of calmodulin should theoretically lead to uncontrolled elevation of intracellular Ca(2+). Paradoxically, classical anti-psych...

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Detalles Bibliográficos
Autores principales: Oláh, Zoltán, Jósvay, Katalin, Pecze, László, Letoha, Tamás, Babai, Norbert, Budai, Dénes, Ötvös, Ferenc, Szalma, Sándor, Vizler, Csaba
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1890308/
https://www.ncbi.nlm.nih.gov/pubmed/17579717
http://dx.doi.org/10.1371/journal.pone.0000545

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