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bZIPDB : A database of regulatory information for human bZIP transcription factors

BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCR...

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Autores principales: Ryu, Taewoo, Jung, Juhyun, Lee, Sunjae, Nam, Ho Jung, Hong, Sun Woo, Yoo, Jae Wook, Lee, Dong-ki, Lee, Doheon
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891292/
https://www.ncbi.nlm.nih.gov/pubmed/17535445
http://dx.doi.org/10.1186/1471-2164-8-136
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author Ryu, Taewoo
Jung, Juhyun
Lee, Sunjae
Nam, Ho Jung
Hong, Sun Woo
Yoo, Jae Wook
Lee, Dong-ki
Lee, Doheon
author_facet Ryu, Taewoo
Jung, Juhyun
Lee, Sunjae
Nam, Ho Jung
Hong, Sun Woo
Yoo, Jae Wook
Lee, Dong-ki
Lee, Doheon
author_sort Ryu, Taewoo
collection PubMed
description BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCRIPTION: We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information. CONCLUSION: bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at .
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spelling pubmed-18912922007-06-13 bZIPDB : A database of regulatory information for human bZIP transcription factors Ryu, Taewoo Jung, Juhyun Lee, Sunjae Nam, Ho Jung Hong, Sun Woo Yoo, Jae Wook Lee, Dong-ki Lee, Doheon BMC Genomics Database BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCRIPTION: We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information. CONCLUSION: bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at . BioMed Central 2007-05-30 /pmc/articles/PMC1891292/ /pubmed/17535445 http://dx.doi.org/10.1186/1471-2164-8-136 Text en Copyright © 2007 Ryu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database
Ryu, Taewoo
Jung, Juhyun
Lee, Sunjae
Nam, Ho Jung
Hong, Sun Woo
Yoo, Jae Wook
Lee, Dong-ki
Lee, Doheon
bZIPDB : A database of regulatory information for human bZIP transcription factors
title bZIPDB : A database of regulatory information for human bZIP transcription factors
title_full bZIPDB : A database of regulatory information for human bZIP transcription factors
title_fullStr bZIPDB : A database of regulatory information for human bZIP transcription factors
title_full_unstemmed bZIPDB : A database of regulatory information for human bZIP transcription factors
title_short bZIPDB : A database of regulatory information for human bZIP transcription factors
title_sort bzipdb : a database of regulatory information for human bzip transcription factors
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891292/
https://www.ncbi.nlm.nih.gov/pubmed/17535445
http://dx.doi.org/10.1186/1471-2164-8-136
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