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bZIPDB : A database of regulatory information for human bZIP transcription factors
BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCR...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891292/ https://www.ncbi.nlm.nih.gov/pubmed/17535445 http://dx.doi.org/10.1186/1471-2164-8-136 |
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author | Ryu, Taewoo Jung, Juhyun Lee, Sunjae Nam, Ho Jung Hong, Sun Woo Yoo, Jae Wook Lee, Dong-ki Lee, Doheon |
author_facet | Ryu, Taewoo Jung, Juhyun Lee, Sunjae Nam, Ho Jung Hong, Sun Woo Yoo, Jae Wook Lee, Dong-ki Lee, Doheon |
author_sort | Ryu, Taewoo |
collection | PubMed |
description | BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCRIPTION: We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information. CONCLUSION: bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at . |
format | Text |
id | pubmed-1891292 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18912922007-06-13 bZIPDB : A database of regulatory information for human bZIP transcription factors Ryu, Taewoo Jung, Juhyun Lee, Sunjae Nam, Ho Jung Hong, Sun Woo Yoo, Jae Wook Lee, Dong-ki Lee, Doheon BMC Genomics Database BACKGROUND: Basic region-leucine zipper (bZIP) proteins are a class of transcription factors (TFs) that play diverse roles in eukaryotes. Malfunctions in these proteins lead to cancer and various other diseases. For detailed characterization of these TFs, further public resources are required. DESCRIPTION: We constructed a database, designated bZIPDB, containing information on 49 human bZIP TFs, by means of automated literature collection and manual curation. bZIPDB aims to provide public data required for deciphering the gene regulatory network of the human bZIP family, e.g., evaluation or reference information for the identification of regulatory modules. The resources provided by bZIPDB include (1) protein interaction data including direct binding, phosphorylation and functional associations between bZIP TFs and other cellular proteins, along with other types of interactions, (2) bZIP TF-target gene relationships, (3) the cellular network of bZIP TFs in particular cell lines, and (4) gene information and ontology. In the current version of the database, 721 protein interactions and 560 TF-target gene relationships are recorded. bZIPDB is annually updated for the newly discovered information. CONCLUSION: bZIPDB is a repository of detailed regulatory information for human bZIP TFs that is collected and processed from the literature, designed to facilitate analysis of this protein family. bZIPDB is available for public use at . BioMed Central 2007-05-30 /pmc/articles/PMC1891292/ /pubmed/17535445 http://dx.doi.org/10.1186/1471-2164-8-136 Text en Copyright © 2007 Ryu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Ryu, Taewoo Jung, Juhyun Lee, Sunjae Nam, Ho Jung Hong, Sun Woo Yoo, Jae Wook Lee, Dong-ki Lee, Doheon bZIPDB : A database of regulatory information for human bZIP transcription factors |
title | bZIPDB : A database of regulatory information for human bZIP transcription factors |
title_full | bZIPDB : A database of regulatory information for human bZIP transcription factors |
title_fullStr | bZIPDB : A database of regulatory information for human bZIP transcription factors |
title_full_unstemmed | bZIPDB : A database of regulatory information for human bZIP transcription factors |
title_short | bZIPDB : A database of regulatory information for human bZIP transcription factors |
title_sort | bzipdb : a database of regulatory information for human bzip transcription factors |
topic | Database |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891292/ https://www.ncbi.nlm.nih.gov/pubmed/17535445 http://dx.doi.org/10.1186/1471-2164-8-136 |
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