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IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68

BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc r...

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Detalles Bibliográficos
Autores principales: Rosa, Gustavo T., Gillet, Laurent, Smith, Christopher M., de Lima, Brigitte D., Stevenson, Philip G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891442/
https://www.ncbi.nlm.nih.gov/pubmed/17593961
http://dx.doi.org/10.1371/journal.pone.0000560
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author Rosa, Gustavo T.
Gillet, Laurent
Smith, Christopher M.
de Lima, Brigitte D.
Stevenson, Philip G.
author_facet Rosa, Gustavo T.
Gillet, Laurent
Smith, Christopher M.
de Lima, Brigitte D.
Stevenson, Philip G.
author_sort Rosa, Gustavo T.
collection PubMed
description BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor(+) cells. PRINCIPAL FINDINGS: Immune sera blocked murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged, but the infection was not abortive and new virus production soon overwhelmed infected cultures. Lytically infected macrophages down-regulated MHC class I-restricted antigen presentation, endocytosis and their response to LPS. CONCLUSIONS: IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68.
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spelling pubmed-18914422007-06-27 IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68 Rosa, Gustavo T. Gillet, Laurent Smith, Christopher M. de Lima, Brigitte D. Stevenson, Philip G. PLoS One Research Article BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor(+) cells. PRINCIPAL FINDINGS: Immune sera blocked murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged, but the infection was not abortive and new virus production soon overwhelmed infected cultures. Lytically infected macrophages down-regulated MHC class I-restricted antigen presentation, endocytosis and their response to LPS. CONCLUSIONS: IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68. Public Library of Science 2007-06-27 /pmc/articles/PMC1891442/ /pubmed/17593961 http://dx.doi.org/10.1371/journal.pone.0000560 Text en Rosa et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Rosa, Gustavo T.
Gillet, Laurent
Smith, Christopher M.
de Lima, Brigitte D.
Stevenson, Philip G.
IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title_full IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title_fullStr IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title_full_unstemmed IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title_short IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68
title_sort igg fc receptors provide an alternative infection route for murine gamma-herpesvirus-68
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891442/
https://www.ncbi.nlm.nih.gov/pubmed/17593961
http://dx.doi.org/10.1371/journal.pone.0000560
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