A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations

In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous do...

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Autores principales: Bhargavi, Ryavarapu, Vishwakarma, Siddharth, Murty, Upadhyayula Suryanarayana
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics Publishing Group 2005
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891629/
https://www.ncbi.nlm.nih.gov/pubmed/17597853
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author Bhargavi, Ryavarapu
Vishwakarma, Siddharth
Murty, Upadhyayula Suryanarayana
author_facet Bhargavi, Ryavarapu
Vishwakarma, Siddharth
Murty, Upadhyayula Suryanarayana
author_sort Bhargavi, Ryavarapu
collection PubMed
description In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains. Four species namely C. vishnui, C. annulus, C. pipiens, C. quiquefasciatusshowed high sequence (98­100%) and RNA secondary structure similarity. The ITS2 similarity among different species is high despite their varying geographical locations. Several common features of secondary structure are shared among these species, with some of them supported by compensatory changes, suggesting the significant role by ITS2 as an RNA domain during ribosome biogenesis.
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spelling pubmed-18916292007-06-27 A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations Bhargavi, Ryavarapu Vishwakarma, Siddharth Murty, Upadhyayula Suryanarayana Bioinformation Hypothesis In the present study, sequence and structural analysis of ITS2 region (the spacer segment between 5.8S and 28S rRNA of mature rRNA sequences) of 7 Culex species belonging to 5 different geographical locations was carried out. Alignment of the ITS2 sequence from the 7 species revealed 8 homologous domains. Four species namely C. vishnui, C. annulus, C. pipiens, C. quiquefasciatusshowed high sequence (98­100%) and RNA secondary structure similarity. The ITS2 similarity among different species is high despite their varying geographical locations. Several common features of secondary structure are shared among these species, with some of them supported by compensatory changes, suggesting the significant role by ITS2 as an RNA domain during ribosome biogenesis. Biomedical Informatics Publishing Group 2005-10-05 /pmc/articles/PMC1891629/ /pubmed/17597853 Text en © 2005 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Bhargavi, Ryavarapu
Vishwakarma, Siddharth
Murty, Upadhyayula Suryanarayana
A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title_full A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title_fullStr A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title_full_unstemmed A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title_short A secondary structural common core in the ribosomal ITS2 (internal transcribed spacer) of Culexspecies from diverse geographical locations
title_sort secondary structural common core in the ribosomal its2 (internal transcribed spacer) of culexspecies from diverse geographical locations
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891629/
https://www.ncbi.nlm.nih.gov/pubmed/17597853
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