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Molecular drug targets and structure based drug design: A holistic approach
Access to the complete human genome sequence as well as to the complete sequences of pathogenic organisms provides information that can result in an avalanche of therapeutic targets. Structure-based design is one of the first techniques to be used in drug design. Structure based design refers specif...
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Formato: | Texto |
Lenguaje: | English |
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Biomedical Informatics Publishing Group
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891708/ https://www.ncbi.nlm.nih.gov/pubmed/17597912 |
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author | Singh, Shailza Malik, Balwant Kumar Sharma, Durlabh Kumar |
author_facet | Singh, Shailza Malik, Balwant Kumar Sharma, Durlabh Kumar |
author_sort | Singh, Shailza |
collection | PubMed |
description | Access to the complete human genome sequence as well as to the complete sequences of pathogenic organisms provides information that can result in an avalanche of therapeutic targets. Structure-based design is one of the first techniques to be used in drug design. Structure based design refers specifically to finding and complementing the 3D structure (binding and/or active site) of a target molecule such as a receptor protein. The aim of this review is to give an outline of studies in the field of structure based drug design that has helped in the discovery process of new drugs. The emphasis will be on comparative/homology modeling. |
format | Text |
id | pubmed-1891708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Biomedical Informatics Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-18917082007-06-27 Molecular drug targets and structure based drug design: A holistic approach Singh, Shailza Malik, Balwant Kumar Sharma, Durlabh Kumar Bioinformation Current Trends Access to the complete human genome sequence as well as to the complete sequences of pathogenic organisms provides information that can result in an avalanche of therapeutic targets. Structure-based design is one of the first techniques to be used in drug design. Structure based design refers specifically to finding and complementing the 3D structure (binding and/or active site) of a target molecule such as a receptor protein. The aim of this review is to give an outline of studies in the field of structure based drug design that has helped in the discovery process of new drugs. The emphasis will be on comparative/homology modeling. Biomedical Informatics Publishing Group 2006-12-23 /pmc/articles/PMC1891708/ /pubmed/17597912 Text en © 2005 Biomedical Informatics Publishing Group This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited. |
spellingShingle | Current Trends Singh, Shailza Malik, Balwant Kumar Sharma, Durlabh Kumar Molecular drug targets and structure based drug design: A holistic approach |
title | Molecular drug targets and structure based drug design: A holistic approach |
title_full | Molecular drug targets and structure based drug design: A holistic approach |
title_fullStr | Molecular drug targets and structure based drug design: A holistic approach |
title_full_unstemmed | Molecular drug targets and structure based drug design: A holistic approach |
title_short | Molecular drug targets and structure based drug design: A holistic approach |
title_sort | molecular drug targets and structure based drug design: a holistic approach |
topic | Current Trends |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891708/ https://www.ncbi.nlm.nih.gov/pubmed/17597912 |
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