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Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women
BACKGROUND: Persistent organic pollutants (POPs) can influence the immune system, possibly increasing the risk of rheumatoid arthritis (RA). In addition, as metabolic change due to obesity has been proposed as one mechanism of osteoarthritis (OA), POPs stored in adipose tissue may be also associated...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892126/ https://www.ncbi.nlm.nih.gov/pubmed/17589595 http://dx.doi.org/10.1289/ehp.9887 |
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author | Lee, Duk-Hee Steffes, Michael Jacobs, David R. |
author_facet | Lee, Duk-Hee Steffes, Michael Jacobs, David R. |
author_sort | Lee, Duk-Hee |
collection | PubMed |
description | BACKGROUND: Persistent organic pollutants (POPs) can influence the immune system, possibly increasing the risk of rheumatoid arthritis (RA). In addition, as metabolic change due to obesity has been proposed as one mechanism of osteoarthritis (OA), POPs stored in adipose tissue may be also associated with OA. OBJECTIVE: Our goal in this study was to examine associations of background exposure to POPs with arthritis among the general population. DESIGN: We investigated cross-sectional associations of serum POPs concentrations with the prevalence of self-reported arthritis in 1,721 adults ≥ 20 years of age in the National Health and Nutrition Examination Survey 1999–2002. RESULTS: Among several POPs, dioxin-like polychlorinated biphenyls (PCBs) or nondioxin-like PCBs were positively associated with arthritis in women. After adjusting for possible confounders, odds ratios (ORs) were 1.0, 2.1, 3.5, and 2.9 across quartiles of dioxin-like PCBs (p for trend = 0.02). Corresponding figures for nondioxin-like PCBs were 1.0, 1.6, 2.6, and 2.5 (p for trend = 0.02). Organochlorine (OC) pesticides were also weakly associated with arthritis in women. For subtypes of arthritis, respectively, RA was more strongly associated with PCBs than was OA. The adjusted ORs for RA were 1.0, 7.6, 6.1, and 8.5 for dioxin-like PCBs (p for trend = 0.05), 1.0, 2.2, 4.4, and 5.4 for nondioxin-like PCBs (p for trend < 0.01), and 1.0, 2.8, 2.7, and 3.5 for OC pesticides (p for trend = 0.15). POPs in men did not show any clear relation with arthritis. CONCLUSIONS: The possibility that background exposure to PCBs may be involved in pathogenesis of arthritis, especially RA, in women should be investigated in prospective studies. |
format | Text |
id | pubmed-1892126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-18921262007-06-22 Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women Lee, Duk-Hee Steffes, Michael Jacobs, David R. Environ Health Perspect Research BACKGROUND: Persistent organic pollutants (POPs) can influence the immune system, possibly increasing the risk of rheumatoid arthritis (RA). In addition, as metabolic change due to obesity has been proposed as one mechanism of osteoarthritis (OA), POPs stored in adipose tissue may be also associated with OA. OBJECTIVE: Our goal in this study was to examine associations of background exposure to POPs with arthritis among the general population. DESIGN: We investigated cross-sectional associations of serum POPs concentrations with the prevalence of self-reported arthritis in 1,721 adults ≥ 20 years of age in the National Health and Nutrition Examination Survey 1999–2002. RESULTS: Among several POPs, dioxin-like polychlorinated biphenyls (PCBs) or nondioxin-like PCBs were positively associated with arthritis in women. After adjusting for possible confounders, odds ratios (ORs) were 1.0, 2.1, 3.5, and 2.9 across quartiles of dioxin-like PCBs (p for trend = 0.02). Corresponding figures for nondioxin-like PCBs were 1.0, 1.6, 2.6, and 2.5 (p for trend = 0.02). Organochlorine (OC) pesticides were also weakly associated with arthritis in women. For subtypes of arthritis, respectively, RA was more strongly associated with PCBs than was OA. The adjusted ORs for RA were 1.0, 7.6, 6.1, and 8.5 for dioxin-like PCBs (p for trend = 0.05), 1.0, 2.2, 4.4, and 5.4 for nondioxin-like PCBs (p for trend < 0.01), and 1.0, 2.8, 2.7, and 3.5 for OC pesticides (p for trend = 0.15). POPs in men did not show any clear relation with arthritis. CONCLUSIONS: The possibility that background exposure to PCBs may be involved in pathogenesis of arthritis, especially RA, in women should be investigated in prospective studies. National Institute of Environmental Health Sciences 2007-06 2007-02-20 /pmc/articles/PMC1892126/ /pubmed/17589595 http://dx.doi.org/10.1289/ehp.9887 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Lee, Duk-Hee Steffes, Michael Jacobs, David R. Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title | Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title_full | Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title_fullStr | Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title_full_unstemmed | Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title_short | Positive Associations of Serum Concentration of Polychlorinated Biphenyls or Organochlorine Pesticides with Self-Reported Arthritis, Especially Rheumatoid Type, in Women |
title_sort | positive associations of serum concentration of polychlorinated biphenyls or organochlorine pesticides with self-reported arthritis, especially rheumatoid type, in women |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892126/ https://www.ncbi.nlm.nih.gov/pubmed/17589595 http://dx.doi.org/10.1289/ehp.9887 |
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