Ligand Binding and Circular Permutation Modify Residue Interaction Network in DHFR

Residue interaction networks and loop motions are important for catalysis in dihydrofolate reductase (DHFR). Here, we investigate the effects of ligand binding and chain connectivity on network communication in DHFR. We carry out systematic network analysis and molecular dynamics simulations of the...

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Detalles Bibliográficos
Autores principales: Hu, Zengjian, Bowen, Donnell, Southerland, William M, del Sol, Antonio, Pan, Yongping, Nussinov, Ruth, Ma, Buyong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892607/
https://www.ncbi.nlm.nih.gov/pubmed/17571919
http://dx.doi.org/10.1371/journal.pcbi.0030117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892607/
https://www.ncbi.nlm.nih.gov/pubmed/17571919
http://dx.doi.org/10.1371/journal.pcbi.0030117

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