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Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants
BACKGROUND: Leptin and its soluble receptor (sOB-R) are important to regulation of body composition but there are no data on the developmental variations in these plasma variables and their relationship with body composition measurements, METHODS: Weight, length, and body composition (bone, fat and...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894811/ https://www.ncbi.nlm.nih.gov/pubmed/17547758 http://dx.doi.org/10.1186/1475-2891-6-11 |
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author | Koo, Winston WK Hammami, Mouhanad Hockman, Elaine M |
author_facet | Koo, Winston WK Hammami, Mouhanad Hockman, Elaine M |
author_sort | Koo, Winston WK |
collection | PubMed |
description | BACKGROUND: Leptin and its soluble receptor (sOB-R) are important to regulation of body composition but there are no data on the developmental variations in these plasma variables and their relationship with body composition measurements, METHODS: Weight, length, and body composition (bone, fat and lean mass) by dual energy absorptiometry, and plasma variables were measured in healthy infants at 2, 4, 8 and 12 months. RESULTS: 15 whites and 29 African Americans (21 males and 23 females) with mean birth weight 3357 +/- 45 (SEM) g and gestation of 39.3 +/- 0.17 weeks were studied. The overall Z score for weight, length and weight for length during the study were 0.00 +/- 0.15, -0.08 +/- 0.11 and 0.12 +/- 0.14 respectively. With increasing age, plasma leptin (1.0 to 18.2, median 5.5 ng/mL) and sOB-R:leptin molar ratio (10.1 to 247.4, median 59.9) were lowered (r = -0.47, p < 0.01; and r = -0.37, p < 0.05 respectively), best predicted by weight Z score and percentage of fat mass, and higher in African American and female. Presence of body composition measurements eliminated the race and gender effect on the plasma variables. Plasma sOB-R (49.5 to 173.9, median 81.3 ng/mL) did not change significantly with age and was correlated and predicted only by body composition measurements. CONCLUSION: In healthy growing infants, plasma leptin but not sOB-R decreases with age. Gender, race and anthropometric measurements are additional physiological determinants predictive of plasma leptin and the receptor:ligand ratio. However, body composition is the only variable that can predict plasma leptin and its soluble receptor and the receptor: ligand ratio; and body composition measurements eliminated the race and gender effect on these plasma variables. |
format | Text |
id | pubmed-1894811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-18948112007-06-20 Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants Koo, Winston WK Hammami, Mouhanad Hockman, Elaine M Nutr J Research BACKGROUND: Leptin and its soluble receptor (sOB-R) are important to regulation of body composition but there are no data on the developmental variations in these plasma variables and their relationship with body composition measurements, METHODS: Weight, length, and body composition (bone, fat and lean mass) by dual energy absorptiometry, and plasma variables were measured in healthy infants at 2, 4, 8 and 12 months. RESULTS: 15 whites and 29 African Americans (21 males and 23 females) with mean birth weight 3357 +/- 45 (SEM) g and gestation of 39.3 +/- 0.17 weeks were studied. The overall Z score for weight, length and weight for length during the study were 0.00 +/- 0.15, -0.08 +/- 0.11 and 0.12 +/- 0.14 respectively. With increasing age, plasma leptin (1.0 to 18.2, median 5.5 ng/mL) and sOB-R:leptin molar ratio (10.1 to 247.4, median 59.9) were lowered (r = -0.47, p < 0.01; and r = -0.37, p < 0.05 respectively), best predicted by weight Z score and percentage of fat mass, and higher in African American and female. Presence of body composition measurements eliminated the race and gender effect on the plasma variables. Plasma sOB-R (49.5 to 173.9, median 81.3 ng/mL) did not change significantly with age and was correlated and predicted only by body composition measurements. CONCLUSION: In healthy growing infants, plasma leptin but not sOB-R decreases with age. Gender, race and anthropometric measurements are additional physiological determinants predictive of plasma leptin and the receptor:ligand ratio. However, body composition is the only variable that can predict plasma leptin and its soluble receptor and the receptor: ligand ratio; and body composition measurements eliminated the race and gender effect on these plasma variables. BioMed Central 2007-06-04 /pmc/articles/PMC1894811/ /pubmed/17547758 http://dx.doi.org/10.1186/1475-2891-6-11 Text en Copyright © 2007 Koo et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Koo, Winston WK Hammami, Mouhanad Hockman, Elaine M Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title | Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title_full | Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title_fullStr | Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title_full_unstemmed | Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title_short | Developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
title_sort | developmental variations in plasma leptin, leptin soluble receptor and their molar ratio in healthy infants |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894811/ https://www.ncbi.nlm.nih.gov/pubmed/17547758 http://dx.doi.org/10.1186/1475-2891-6-11 |
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