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Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases

BACKGROUND: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environm...

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Autores principales: Mossman, Brooke T, Borm, Paul J, Castranova, Vincent, Costa, Daniel L, Donaldson, Kenneth, Kleeberger, Steven R
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894816/
https://www.ncbi.nlm.nih.gov/pubmed/17537262
http://dx.doi.org/10.1186/1743-8977-4-4
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author Mossman, Brooke T
Borm, Paul J
Castranova, Vincent
Costa, Daniel L
Donaldson, Kenneth
Kleeberger, Steven R
author_facet Mossman, Brooke T
Borm, Paul J
Castranova, Vincent
Costa, Daniel L
Donaldson, Kenneth
Kleeberger, Steven R
author_sort Mossman, Brooke T
collection PubMed
description BACKGROUND: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health. RESULTS: The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates. CONCLUSION: New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations.
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spelling pubmed-18948162007-06-20 Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases Mossman, Brooke T Borm, Paul J Castranova, Vincent Costa, Daniel L Donaldson, Kenneth Kleeberger, Steven R Part Fibre Toxicol Commentary BACKGROUND: A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the eighth in a series of transatlantic conferences first held in Penarth, Wales, at the Medical Research Council Pneumoconiosis Unit (1979), that have fostered long-standing collaborations between researchers in the fields of mineralogy, cell and molecular biology, pathology, toxicology, and environmental/occupational health. RESULTS: The goal of this meeting, which was largely supported by a conference grant from the NHLBI, was to assemble a group of clinical and basic research scientists who presented and discussed new data on the mechanistic effects of inhaled particulates on the onset and development of morbidity and mortality in the lung and cardiovascular system. Another outcome of the meeting was the elucidation of a number of host susceptibility factors implicated in adverse health effects associated with inhaled pathogenic particulates. CONCLUSION: New models and data presented supported the paradigm that both genetic and environmental (and occupational) factors affect disease outcomes from inhaled particulates as well as cardiopulmonary responses. These future studies are encouraged to allow the design of appropriate strategies for prevention and treatment of particulate-associated morbidity and mortality, especially in susceptible populations. BioMed Central 2007-05-30 /pmc/articles/PMC1894816/ /pubmed/17537262 http://dx.doi.org/10.1186/1743-8977-4-4 Text en Copyright © 2007 Mossman et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Mossman, Brooke T
Borm, Paul J
Castranova, Vincent
Costa, Daniel L
Donaldson, Kenneth
Kleeberger, Steven R
Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title_full Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title_fullStr Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title_full_unstemmed Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title_short Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
title_sort mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894816/
https://www.ncbi.nlm.nih.gov/pubmed/17537262
http://dx.doi.org/10.1186/1743-8977-4-4
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