Canine and Human Visual Cortex Intact and Responsive Despite Early Retinal Blindness from RPE65 Mutation

BACKGROUND: RPE65 is an essential molecule in the retinoid-visual cycle, and RPE65 gene mutations cause the congenital human blindness known as Leber congenital amaurosis (LCA). Somatic gene therapy delivered to the retina of blind dogs with an RPE65 mutation dramatically restores retinal physiology...

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Detalles Bibliográficos
Autores principales: Aguirre, Geoffrey K, Komáromy, András M, Cideciyan, Artur V, Brainard, David H, Aleman, Tomas S, Roman, Alejandro J, Avants, Brian B, Gee, James C, Korczykowski, Marc, Hauswirth, William W, Acland, Gregory M, Aguirre, Gustavo D
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896221/
https://www.ncbi.nlm.nih.gov/pubmed/17594175
http://dx.doi.org/10.1371/journal.pmed.0040230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1896221/
https://www.ncbi.nlm.nih.gov/pubmed/17594175
http://dx.doi.org/10.1371/journal.pmed.0040230

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