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SNPSTR: a database of compound microsatellite-SNP markers
There has been widespread and growing interest in genetic markers suitable for drawing population genetic inferences about past demographic events and to detect the effects of selection. In addition to single nucleotide polymorphisms (SNPs), microsatellites (or short tandem repeats, STRs) have recei...
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899107/ https://www.ncbi.nlm.nih.gov/pubmed/17202172 http://dx.doi.org/10.1093/nar/gkl806 |
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author | Agrafioti, I. Stumpf, M. P. H. |
author_facet | Agrafioti, I. Stumpf, M. P. H. |
author_sort | Agrafioti, I. |
collection | PubMed |
description | There has been widespread and growing interest in genetic markers suitable for drawing population genetic inferences about past demographic events and to detect the effects of selection. In addition to single nucleotide polymorphisms (SNPs), microsatellites (or short tandem repeats, STRs) have received great attention in the analysis of human population history. In the SNPSTR database () we catalogue a relatively new type of compound genetic marker called SNPSTR which combines a microsatellite marker (STR) with one or more tightly linked SNPs. Here, the SNP(s) and the microsatellite are less than 250 bp apart so each SNPSTR can be considered a small haplotype with no recombination occurring between the two individual markers. Thus, SNPSTRs have the potential to become a very useful tool in the field of population genetics. The SNPSTR database contains all inferable human SNPSTRs as well as those in mouse, rat, dog and chicken, i.e. all model organisms for which extensive SNP datasets are available. |
format | Text |
id | pubmed-1899107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-18991072007-06-26 SNPSTR: a database of compound microsatellite-SNP markers Agrafioti, I. Stumpf, M. P. H. Nucleic Acids Res Articles There has been widespread and growing interest in genetic markers suitable for drawing population genetic inferences about past demographic events and to detect the effects of selection. In addition to single nucleotide polymorphisms (SNPs), microsatellites (or short tandem repeats, STRs) have received great attention in the analysis of human population history. In the SNPSTR database () we catalogue a relatively new type of compound genetic marker called SNPSTR which combines a microsatellite marker (STR) with one or more tightly linked SNPs. Here, the SNP(s) and the microsatellite are less than 250 bp apart so each SNPSTR can be considered a small haplotype with no recombination occurring between the two individual markers. Thus, SNPSTRs have the potential to become a very useful tool in the field of population genetics. The SNPSTR database contains all inferable human SNPSTRs as well as those in mouse, rat, dog and chicken, i.e. all model organisms for which extensive SNP datasets are available. Oxford University Press 2007-01 /pmc/articles/PMC1899107/ /pubmed/17202172 http://dx.doi.org/10.1093/nar/gkl806 Text en © 2006 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Agrafioti, I. Stumpf, M. P. H. SNPSTR: a database of compound microsatellite-SNP markers |
title | SNPSTR: a database of compound microsatellite-SNP markers |
title_full | SNPSTR: a database of compound microsatellite-SNP markers |
title_fullStr | SNPSTR: a database of compound microsatellite-SNP markers |
title_full_unstemmed | SNPSTR: a database of compound microsatellite-SNP markers |
title_short | SNPSTR: a database of compound microsatellite-SNP markers |
title_sort | snpstr: a database of compound microsatellite-snp markers |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899107/ https://www.ncbi.nlm.nih.gov/pubmed/17202172 http://dx.doi.org/10.1093/nar/gkl806 |
work_keys_str_mv | AT agrafiotii snpstradatabaseofcompoundmicrosatellitesnpmarkers AT stumpfmph snpstradatabaseofcompoundmicrosatellitesnpmarkers |