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Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma

BACKGROUND: N-acetyltransferase 1 (NAT1) and 2 (NAT2) are polymorphic isoenzymes responsible for the metabolism of numerous drugs and carcinogens. Acetylation catalyzed by NAT1 and NAT2 are important in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. I...

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Detalles Bibliográficos
Autores principales:	Mahid, Suhal S, Colliver, Daniel W, Crawford, Nigel PS, Martini, Benjamin D, Doll, Mark A, Hein, David W, Cobbs, Gary A, Petras, Robert E, Galandiuk, Susan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903350/ https://www.ncbi.nlm.nih.gov/pubmed/17537267 http://dx.doi.org/10.1186/1471-2350-8-28

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