Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Th1 response in a mouse hepatic cancer model

BACKGROUND: The novel cytokine, interleukin (IL)-18, is a strong interferon-γ inducer and costimulatory factor in Th1 cell activation. IL-18 triggers IFN-γ production and enhances cytolytic activity in both T and NK cells. However, the exact mechanism of antitumor action of IL-18 remains to be clari...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Chi-Young, Lee, Jienny, Kim, Eun-Young, Park, Hae-Jung, Kwon, Choon-Hyuck, Joh, Jae-Won, Kim, Sung-Joo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903361/
https://www.ncbi.nlm.nih.gov/pubmed/17519043
http://dx.doi.org/10.1186/1471-2407-7-87

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903361/
https://www.ncbi.nlm.nih.gov/pubmed/17519043
http://dx.doi.org/10.1186/1471-2407-7-87

Ejemplares similares