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Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Th1 response in a mouse hepatic cancer model
BACKGROUND: The novel cytokine, interleukin (IL)-18, is a strong interferon-γ inducer and costimulatory factor in Th1 cell activation. IL-18 triggers IFN-γ production and enhances cytolytic activity in both T and NK cells. However, the exact mechanism of antitumor action of IL-18 remains to be clari...
Autores principales: | Chang, Chi-Young, Lee, Jienny, Kim, Eun-Young, Park, Hae-Jung, Kwon, Choon-Hyuck, Joh, Jae-Won, Kim, Sung-Joo |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903361/ https://www.ncbi.nlm.nih.gov/pubmed/17519043 http://dx.doi.org/10.1186/1471-2407-7-87 |
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