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Genes invoked in the ovarian transition to menopause

Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene–protein analy...

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Detalles Bibliográficos
Autores principales: Zimon, Alison, Erat, Anna, Wald, Tiffany Von, Bissell, Brad, Koulova, Anna, Choi, Chu H., Bachvarov, Dimcho, Reindollar, Richard H., Usheva, Anny
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904106/
https://www.ncbi.nlm.nih.gov/pubmed/16807318
http://dx.doi.org/10.1093/nar/gkl387
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author Zimon, Alison
Erat, Anna
Wald, Tiffany Von
Bissell, Brad
Koulova, Anna
Choi, Chu H.
Bachvarov, Dimcho
Reindollar, Richard H.
Usheva, Anny
author_facet Zimon, Alison
Erat, Anna
Wald, Tiffany Von
Bissell, Brad
Koulova, Anna
Choi, Chu H.
Bachvarov, Dimcho
Reindollar, Richard H.
Usheva, Anny
author_sort Zimon, Alison
collection PubMed
description Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene–protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expression profiles and protein localization and content patterns in healthy young and perimenopausal mouse ovaries. We report a clear distinction in specific mRNA and protein levels that are noted prior to molecular evidence of steroidogenic failure. In this model, ovarian reproductive aging displays similarities with chronic inflammation and increased sensitivity to environmental cues. Overall, our results indicate the presence of mouse climacteric genes that are likely to be major players in aging-dependent changes in ovarian function.
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spelling pubmed-19041062007-06-28 Genes invoked in the ovarian transition to menopause Zimon, Alison Erat, Anna Wald, Tiffany Von Bissell, Brad Koulova, Anna Choi, Chu H. Bachvarov, Dimcho Reindollar, Richard H. Usheva, Anny Nucleic Acids Res Article Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene–protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expression profiles and protein localization and content patterns in healthy young and perimenopausal mouse ovaries. We report a clear distinction in specific mRNA and protein levels that are noted prior to molecular evidence of steroidogenic failure. In this model, ovarian reproductive aging displays similarities with chronic inflammation and increased sensitivity to environmental cues. Overall, our results indicate the presence of mouse climacteric genes that are likely to be major players in aging-dependent changes in ovarian function. Oxford University Press 2006 2006-06-28 /pmc/articles/PMC1904106/ /pubmed/16807318 http://dx.doi.org/10.1093/nar/gkl387 Text en © 2006 The Author(s)
spellingShingle Article
Zimon, Alison
Erat, Anna
Wald, Tiffany Von
Bissell, Brad
Koulova, Anna
Choi, Chu H.
Bachvarov, Dimcho
Reindollar, Richard H.
Usheva, Anny
Genes invoked in the ovarian transition to menopause
title Genes invoked in the ovarian transition to menopause
title_full Genes invoked in the ovarian transition to menopause
title_fullStr Genes invoked in the ovarian transition to menopause
title_full_unstemmed Genes invoked in the ovarian transition to menopause
title_short Genes invoked in the ovarian transition to menopause
title_sort genes invoked in the ovarian transition to menopause
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904106/
https://www.ncbi.nlm.nih.gov/pubmed/16807318
http://dx.doi.org/10.1093/nar/gkl387
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