HIV-1 Vpr activates the G(2 )checkpoint through manipulation of the ubiquitin proteasome system

HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G(2 )and induction of apoptosis. In the present study, we investigate the role of the ubiquitin/proteasome system (UPS) in the above activity of V...

Descripción completa

Detalles Bibliográficos
Autores principales: DeHart, Jason L, Zimmerman, Erik S, Ardon, Orly, Monteiro-Filho, Carlos MR, Argañaraz, Enrique R, Planelles, Vicente
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904188/
https://www.ncbi.nlm.nih.gov/pubmed/17559673
http://dx.doi.org/10.1186/1743-422X-4-57

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904188/
https://www.ncbi.nlm.nih.gov/pubmed/17559673
http://dx.doi.org/10.1186/1743-422X-4-57

Ejemplares similares