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HIV-1 Vpr activates the G(2 )checkpoint through manipulation of the ubiquitin proteasome system
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G(2 )and induction of apoptosis. In the present study, we investigate the role of the ubiquitin/proteasome system (UPS) in the above activity of V...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904188/ https://www.ncbi.nlm.nih.gov/pubmed/17559673 http://dx.doi.org/10.1186/1743-422X-4-57 |