t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia

Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc)...

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Detalles Bibliográficos
Autores principales: Liu, Delong, Shimonov, Josif, Primanneni, Suneeta, Lai, Yongrong, Ahmed, Tauseef, Seiter, Karen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904237/
https://www.ncbi.nlm.nih.gov/pubmed/17547754
http://dx.doi.org/10.1186/1476-4598-6-35
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author Liu, Delong
Shimonov, Josif
Primanneni, Suneeta
Lai, Yongrong
Ahmed, Tauseef
Seiter, Karen
author_facet Liu, Delong
Shimonov, Josif
Primanneni, Suneeta
Lai, Yongrong
Ahmed, Tauseef
Seiter, Karen
author_sort Liu, Delong
collection PubMed
description Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.
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spelling pubmed-19042372007-06-29 t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia Liu, Delong Shimonov, Josif Primanneni, Suneeta Lai, Yongrong Ahmed, Tauseef Seiter, Karen Mol Cancer Short Communication Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma. BioMed Central 2007-06-04 /pmc/articles/PMC1904237/ /pubmed/17547754 http://dx.doi.org/10.1186/1476-4598-6-35 Text en Copyright © 2007 Liu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Liu, Delong
Shimonov, Josif
Primanneni, Suneeta
Lai, Yongrong
Ahmed, Tauseef
Seiter, Karen
t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title_full t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title_fullStr t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title_full_unstemmed t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title_short t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
title_sort t(8;14;18): a 3-way chromosome translocation in two patients with burkitt's lymphoma/leukemia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904237/
https://www.ncbi.nlm.nih.gov/pubmed/17547754
http://dx.doi.org/10.1186/1476-4598-6-35
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