Chemical synthesis of a very long oligoribonucleotide with 2-cyanoethoxymethyl (CEM) as the 2′-O-protecting group: structural identification and biological activity of a synthetic 110mer precursor-microRNA candidate

A long RNA oligomer, a 110mer with the sequence of a precursor-microRNA candidate, has been chemically synthesized in a single synthesizer run by means of standard automated phosphoramidite chemistry. The synthetic method involved the use of 2-cyanoethoxymethyl (CEM), a 2′-hydroxyl protecting group...

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Detalles Bibliográficos
Autores principales: Shiba, Yoshinobu, Masuda, Hirofumi, Watanabe, Naoki, Ego, Takeshi, Takagaki, Kazuchika, Ishiyama, Kouichi, Ohgi, Tadaaki, Yano, Junichi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904286/
https://www.ncbi.nlm.nih.gov/pubmed/17459888
http://dx.doi.org/10.1093/nar/gkm202

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