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Amino acid residues of the Escherichia coli tRNA(m(5)U54)methyltransferase (TrmA) critical for stability, covalent binding of tRNA and enzymatic activity

The Escherichia coli trmA gene encodes the tRNA(m(5)U54)methyltransferase, which catalyses the formation of m(5)U54 in tRNA. During the synthesis of m(5)U54, a covalent 62-kDa TrmA-tRNA intermediate is formed between the amino acid C324 of the enzyme and the 6-carbon of uracil. We have analysed the...

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Detalles Bibliográficos
Autores principales:	Urbonavičius, Jaunius, Jäger, Gunilla, Björk, Glenn R.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904294/ https://www.ncbi.nlm.nih.gov/pubmed/17459887 http://dx.doi.org/10.1093/nar/gkm205

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