High occurrence of BRCA1 intragenic rearrangements in hereditary breast and ovarian cancer syndrome in the Czech Republic

BACKGROUND: Alterations in the highly penetrant cancer susceptibility gene BRCA1 are responsible for the majority of hereditary breast and/or ovarian cancers. However, the number of detected germline mutations has been lower than expected based upon genetic linkage data. Undetected deleterious mutat...

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Detalles Bibliográficos
Autores principales: Vasickova, Petra, Machackova, Eva, Lukesova, Miroslava, Damborsky, Jiri, Horky, Ondrej, Pavlu, Hana, Kuklova, Jitka, Kosinova, Veronika, Navratilova, Marie, Foretova, Lenka
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904436/
https://www.ncbi.nlm.nih.gov/pubmed/17561994
http://dx.doi.org/10.1186/1471-2350-8-32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904436/
https://www.ncbi.nlm.nih.gov/pubmed/17561994
http://dx.doi.org/10.1186/1471-2350-8-32

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