Biochemical characterization of the fidelity of poliovirus RNA-dependent RNA polymerase

BACKGROUND: Putative high mutation rates of RNA viruses are believed to mediate undesirable phenomena, such as emergence of drug resistance. However, very little is known about biochemical fidelity rates for viral RNA-dependent RNA polymerases. Using a recently developed in vitro polymerase assay fo...

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Detalles Bibliográficos
Autores principales: Freistadt, Marion S, Vaccaro, Joseph A, Eberle, Karen E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904441/
https://www.ncbi.nlm.nih.gov/pubmed/17524144
http://dx.doi.org/10.1186/1743-422X-4-44

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