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The long journey to a Systems Biology of neuronal function

Computational neurobiology was born over half a century ago, and has since been consistently at the forefront of modelling in biology. The recent progress of computing power and distributed computing allows the building of models spanning several scales, from the synapse to the brain. Initially focu...

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Detalles Bibliográficos
Autor principal: Le Novère, Nicolas
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904462/
https://www.ncbi.nlm.nih.gov/pubmed/17567903
http://dx.doi.org/10.1186/1752-0509-1-28
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author Le Novère, Nicolas
author_facet Le Novère, Nicolas
author_sort Le Novère, Nicolas
collection PubMed
description Computational neurobiology was born over half a century ago, and has since been consistently at the forefront of modelling in biology. The recent progress of computing power and distributed computing allows the building of models spanning several scales, from the synapse to the brain. Initially focused on electrical processes, the simulation of neuronal function now encompasses signalling pathways and ion diffusion. The flow of quantitative data generated by the "omics" approaches, alongside the progress of live imaging, allows the development of models that will also include gene regulatory networks, protein movements and cellular remodelling. A systems biology of brain functions and disorders can now be envisioned. As it did for the last half century, neuroscience can drive forward the field of systems biology.
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spelling pubmed-19044622007-06-30 The long journey to a Systems Biology of neuronal function Le Novère, Nicolas BMC Syst Biol Commentary Computational neurobiology was born over half a century ago, and has since been consistently at the forefront of modelling in biology. The recent progress of computing power and distributed computing allows the building of models spanning several scales, from the synapse to the brain. Initially focused on electrical processes, the simulation of neuronal function now encompasses signalling pathways and ion diffusion. The flow of quantitative data generated by the "omics" approaches, alongside the progress of live imaging, allows the development of models that will also include gene regulatory networks, protein movements and cellular remodelling. A systems biology of brain functions and disorders can now be envisioned. As it did for the last half century, neuroscience can drive forward the field of systems biology. BioMed Central 2007-06-13 /pmc/articles/PMC1904462/ /pubmed/17567903 http://dx.doi.org/10.1186/1752-0509-1-28 Text en Copyright © 2007 Le Novère; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Le Novère, Nicolas
The long journey to a Systems Biology of neuronal function
title The long journey to a Systems Biology of neuronal function
title_full The long journey to a Systems Biology of neuronal function
title_fullStr The long journey to a Systems Biology of neuronal function
title_full_unstemmed The long journey to a Systems Biology of neuronal function
title_short The long journey to a Systems Biology of neuronal function
title_sort long journey to a systems biology of neuronal function
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904462/
https://www.ncbi.nlm.nih.gov/pubmed/17567903
http://dx.doi.org/10.1186/1752-0509-1-28
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