Cargando…
The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study
BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the ge...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906749/ https://www.ncbi.nlm.nih.gov/pubmed/17577421 http://dx.doi.org/10.1186/1471-2350-8-34 |
_version_ | 1782134018194538496 |
---|---|
author | Hagen, Knut Stovner, Lars J Skorpen, Frank Pettersen, Elin Zwart, John-Anker |
author_facet | Hagen, Knut Stovner, Lars J Skorpen, Frank Pettersen, Elin Zwart, John-Anker |
author_sort | Hagen, Knut |
collection | PubMed |
description | BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the general population. The aim of this prospective study was to evaluate the impact of codon 158 COMT gene polymorphism on survival in a population-based cohort. METHODS: The sample comprised 2979 non-diabetic individuals who participated in the Nord-Trøndelag Health Study (HUNT) in the period 1995–97. The subjects were followed up with respect to mortality throughout year 2004. RESULTS: 212 men and 183 women died during the follow up. No association between codon 158 COMT gene polymorphism and survival was found. The unadjusted relative risk of death by non-ischemic heart diseases with Met/Met or Met/Val genotypes was 3.27 (95% confidence interval, 1.19–9.00) compared to Val/Val genotype. When we adjusted for age, gender, smoking, coffee intake and body mass index the relative risk decreased to 2.89 (95% confidence interval, 1.04–8.00). CONCLUSION: During 10 year of follow-up, the Val158Met polymorphism had no impact on survival in a general population. Difference in mortality rates from non-ischemic heart diseases may be incidental and should be evaluated in other studies. |
format | Text |
id | pubmed-1906749 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-19067492007-07-04 The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study Hagen, Knut Stovner, Lars J Skorpen, Frank Pettersen, Elin Zwart, John-Anker BMC Med Genet Research Article BACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has been related to common diseases like cancer, psychiatric illness and myocardial infarction. Whether the Val158Met polymorphism is associated with survival has not been evaluated in the general population. The aim of this prospective study was to evaluate the impact of codon 158 COMT gene polymorphism on survival in a population-based cohort. METHODS: The sample comprised 2979 non-diabetic individuals who participated in the Nord-Trøndelag Health Study (HUNT) in the period 1995–97. The subjects were followed up with respect to mortality throughout year 2004. RESULTS: 212 men and 183 women died during the follow up. No association between codon 158 COMT gene polymorphism and survival was found. The unadjusted relative risk of death by non-ischemic heart diseases with Met/Met or Met/Val genotypes was 3.27 (95% confidence interval, 1.19–9.00) compared to Val/Val genotype. When we adjusted for age, gender, smoking, coffee intake and body mass index the relative risk decreased to 2.89 (95% confidence interval, 1.04–8.00). CONCLUSION: During 10 year of follow-up, the Val158Met polymorphism had no impact on survival in a general population. Difference in mortality rates from non-ischemic heart diseases may be incidental and should be evaluated in other studies. BioMed Central 2007-06-19 /pmc/articles/PMC1906749/ /pubmed/17577421 http://dx.doi.org/10.1186/1471-2350-8-34 Text en Copyright © 2007 Hagen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hagen, Knut Stovner, Lars J Skorpen, Frank Pettersen, Elin Zwart, John-Anker The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title | The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title_full | The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title_fullStr | The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title_full_unstemmed | The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title_short | The impact of the Catechol-O-methyltransferase Val158Met polymorphism on survival in the general population – the HUNT study |
title_sort | impact of the catechol-o-methyltransferase val158met polymorphism on survival in the general population – the hunt study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906749/ https://www.ncbi.nlm.nih.gov/pubmed/17577421 http://dx.doi.org/10.1186/1471-2350-8-34 |
work_keys_str_mv | AT hagenknut theimpactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT stovnerlarsj theimpactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT skorpenfrank theimpactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT pettersenelin theimpactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT zwartjohnanker theimpactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT hagenknut impactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT stovnerlarsj impactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT skorpenfrank impactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT pettersenelin impactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy AT zwartjohnanker impactofthecatecholomethyltransferaseval158metpolymorphismonsurvivalinthegeneralpopulationthehuntstudy |