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Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Aβ levels

BACKGROUND: Alzheimer's disease (AD) is characterized by a decline in cognitive function and accumulation of amyloid-β peptide (Aβ) in extracellular plaques. Mutations in amyloid precursor protein (APP) and presenilins alter APP metabolism resulting in accumulation of Aβ42, a peptide essential...

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Detalles Bibliográficos
Autores principales:	Lawlor, Patricia A, Bland, Ross J, Das, Pritam, Price, Robert W, Holloway, Vallie, Smithson, Lisa, Dicker, Bridget L, During, Matthew J, Young, Deborah, Golde, Todd E
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906777/ https://www.ncbi.nlm.nih.gov/pubmed/17559680 http://dx.doi.org/10.1186/1750-1326-2-11

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