A pilot study of IL-1 inhibition by anakinra in acute gout

Monosodium urate crystals stimulate monocytes and macrophages to release IL-1β through the NALP3 component of the inflammasome. The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in...

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Detalles Bibliográficos
Autores principales: So, Alexander, De Smedt, Thibaut, Revaz, Sylvie, Tschopp, Jürg
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906806/
https://www.ncbi.nlm.nih.gov/pubmed/17352828
http://dx.doi.org/10.1186/ar2143

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