Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa

BACKGROUND: The nasal tissue uptake and metabolism of ciclesonide, a new-generation corticosteroid under investigation for treatment of allergic rhinitis, to its active metabolite, desisobutyryl-ciclesonide (des-CIC), was evaluated when administered to rabbits in a hypotonic versus an isotonic cicle...

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Detalles Bibliográficos
Autores principales: Sato, Hideyuki, Nave, Ruediger, Nonaka, Takashi, Yoshihisa, Nishibe, Atsuhiro, Nagano, Mochizuki, Tsutomu, Takahama, Shigehiro, Kondo, Shiro, Wingertzahn, Mark
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906851/
https://www.ncbi.nlm.nih.gov/pubmed/17553148
http://dx.doi.org/10.1186/1471-2210-7-7

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